In the late 1970's & throughout the 1980's, during the "Just Say No" campaign, the U.S. Government put forth funding toward cannabis research in hopes that it might produce evidence to support the claims of the harmful and damaging effects of the plant.
Scientists discovered the brain's opiate receptor in 1973, but it was not until 1988 in a government-funded study at the St. Louis University School of Medicine that it was determined that the mammalian brain has receptor sites that respond to compounds found in cannabis. These receptors, named cannabinoid receptors turned out to be the most abundant type of neurotransmitter receptor in the brain!
In 1990, it was announced that a team at the National Institute of Mental health had mapped the DNA sequence that encoded a cannabinoid receptor in the brain and they were able to clone it.
A second cannabinoid named CB2 was also identified at this time, which is naturally present throughout our immune system and the peripheral nervous system. The discovery of these receptors resulted in the uncovering of naturally occurring neurotransmitters called endocannabinoids.
In the pursuit of unearthing the metabolic pathways of phytocannabinoids (CBD) and endocannabinoids, scientists came across an unknown molecular signaling system within the body that is involved in regulating a broad range of biological functions. This system was named the endocannabinoid system (ECS).
Over the years, scientists have found that the ECS performs multiple tasks, but its main goal is always to maintain a stable internal environment despite fluctuations in the external environment. It is the system that creates homeostasis within the body. When an imbalance is detected within our internal environment, the body synthesizes endocannabinoids that interact with the cannabinoid receptors. This stimulates a chemical response that works to return the physiological process back to homeostasis. However, in some cases, there is a deficiency in ECS signaling. This condition is known as Clinical Endocannabinoid Deficiency. Reasons to as why this condition occurs ranges from our body not synthesizing enough endocannabinoids, our bodies not producing enough cannabinoid receptors, an abundance of enzymes that break down cannabinoids, or outside sources such as foods and medications that decrease ECS signaling. The phytocannabinoids contained in CBD can be used to supplement this deficiency. By stimulating and supporting our endocannabinoid system one can find relief from a multitude of illnesses and conditions.
So... In an effort to discredit Cannabis/CBD and medically prove it is dangerous... our US Government actually showed the exact opposite. Shall we say thank you?
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